Abstract
Background. Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients.Material and methods. A total of 93 diabetic and 37 non-diabetic participants were included into the study. Aspirin resistance was measured with a whole-blood desktop platelet function analyzer (PFA-100) with an epinephrine agonist.Results. Altogether 41.9% patients with DM were aspirin non-responders. Aspirin resistance was observed in 43.2% of non-diabetic patients (p = 0.89). Presence of diabetes mellitus had no effect on aspirin response (RR 0.95 (95% CI 0.44–2.05), p = 0.89) in the whole study population. Hypercholesterolemia was the only predictor of aspirin resistance in multivariate analysis in diabetic patients (RR 3.09 (95% CI 1.17–8.16), p = 0.023).Conclusion. The prevalence of aspirin resistance is comparable in diabetic and non-diabetic patients. Hypercholesterolemia is the only independent predictor of aspirin resistance in diabetic patients.
Highlights
Cardiovascular events are still the leading cause of morbidity and mortality in patients with diabetes mellitus (DM) [1]
Groups were comparable in terms of other demographic and laboratory parameters including past/current history of coronary heart disease and hypercholesterolemia (Table I)
Presence of diabetes mellitus did not affect the aspirin response (RR 0.95, p = 0.89) in the whole study population
Summary
Cardiovascular events are still the leading cause of morbidity and mortality in patients with diabetes mellitus (DM) [1]. Independent risk factor for CHD [2]. The Primary Prevention Project trial reported that the cardiovascular risk reduction with aspirin was marginal and non-significant in patients with diabetes [5]. In a meta-analysis of 287 randomized trials, aspirin reduced the risk of ischemic events by 22%, but the risk reduction in the subgroup with diabetes was only 7%, which was not statistically significant [6]. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients. Hypercholesterolemia was the only predictor of aspirin resistance in multivariate analysis in diabetic patients (RR 3.09 (95% CI 1.17–8.16), p = 0.023). The prevalence of aspirin resistance is comparable in diabetic and non-diabetic patients. Hypercholesterolemia is the only independent predictor of aspirin resistance in diabetic patients
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