Abstract
Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and has been documented in Nigerian adult patients but not in the pediatric age group.
Highlights
Immunological pertubations are observed phenomena in Human immunodeficiency virus (HIV) infection both in children and adults
Immunological pertubations are observed phenomena in HIV infection both in children and adults. This combination of autoimmunity and immune dysfunction in patients infected with HIV is an interesting observation [1]
Full blood count was carried out using the Sysmex KX-21N machine while the CD4+ lymphocyte count was done using the CyFlow Counter 1 machine following both reagent and machine instructions. 2.75 mls was collected into a plain bottle for the direct Coombs’ test and anticardiolipin antibody assay
Summary
Immunological pertubations are observed phenomena in HIV infection both in children and adults. This combination of autoimmunity and immune dysfunction in patients infected with HIV is an interesting observation [1]. Antiphospholipid antibodies (aPL) are a heterogeneous group of acquired autoantibodies These could be immunoglobulin G, M, A or a combination of these subtypes. Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and this has been documented in Nigerian adult patients but not in the pediatric age group. To determine the prevalence of antiphospholipid antibodies in HIV-infected children and its association with the clinical stage of infection and possible hematological derangements were the aim of this study
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