Prevalence and risk factors of mycobacterial infections in farm and trade cattle in southwestern Nigeria.

Abstract

We evaluated the prevalence of mycobacterial infections (i.e., Mycobacterium bovis and non-tuberculous mycobacteria [NTM]) and their associated risk factors among cattle herds and trade cattle in southwestern Nigeria. Through cross-sectional study design, cattle herds from three locations were screened using the single intradermal comparative cervical tuberculin test based on two diagnostic standards; more than 4mm (˃4mm) and more than 2mm (˃2mm) cut-off points. Abattoir study involved screening trade cattle for tuberculous lesions. Overall, 515 cattle from 45 herds were screened. Using > 4mm, animal level and herd prevalence of 11.7 and 46.7% were recorded, respectively. Applying the ˃2mm cut-off, animal level and herd prevalence increased to 31.1 and 60.0%, respectively. Significantly, using the ˃2mm cut-off, cattle in medium size herds/extensive management system (OR = 1.6; 95% CI 1.1-2.5) and Sokoto Gudali (OR = 2.3; 95% CI 1.4-3.8) were more at risk of being positive reactors, while Rahaji (OR = 0.3; 95% CI 0.1-0.7) breeds of cattle and cows in the peri-urban area (OR = 0.4; 95% CI 0.2-0.9) were less at risk of being positive reactors. Again, M. avium reactor of 21.7% was observed. In the abattoir, 1797 cattle were examined with 126 lesions suggestive of tuberculosis (TB). Culture/molecular analyses confirmed 2.2% M. bovis and 0.9% NTM infections. Risk factors associated with bovine TB among trade cattle were sex (OR = 4.0; 95% CI 1.2-13.5) and age (OR = 0.3; 95% CI 0.1-0.9). We confirm 11.7% prevalence of mycobacterial infections among populations of cattle screened with breed and herd size being major risk factors.