Abstract

Malaria had been a significant public health challenge in sub-Saharan Africa, particularly affecting children under five years of age, who accounted for over two-thirds of all malaria-related deaths globally. This review examined the prevalence and mortality rates of malaria among this vulnerable population, highlighting key determinants such as socioeconomic status, maternal education, environmental conditions, and access to healthcare. Recent data indicated that approximately 24.2% of children under five in the region are affected by malaria, with socioeconomic disparities exacerbating the risk. The review also discussed the effectiveness of various preventive interventions, including insecticide-treated nets (ITNs), indoor residual spraying (IRS), and seasonal malaria chemoprevention (SMC), emphasizing the need for multifaceted approaches that address both biological and social determinants of health. A comprehensive literature review was conducted to synthesize current research findings and provide insights into the challenges and opportunities for reducing malaria incidence and mortality in this demographic. Ultimately, addressing the complex interplay of risk factors is essential for developing targeted strategies to mitigate the impact of malaria on young children in sub-Saharan Africa. Keywords: Malaria, Children under five, Prevalence, Mortality, Sub-Saharan Africa.

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