Abstract
BackgroundThis study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED.MethodsA total of 1360 type 2 diabetic patients in the Beixinjing community were randomly selected. All participants were given a questionnaire that assessed basic information and subjective symptoms.DED was diagnosed using the revised Japanese DED diagnostic criteria. All subjects underwent a routine ophthalmic examination, corneal sensitivity test, tear film break-up time(BUT) test, Schirmer I test, fluorescein and lissamine green staining(FL) and fundus photography. Diabetic retinopathy (DR) was graded according to the International severity scale of diabetic retinopathy and diabetic macular edema.ResultsOf the 1360 subjects, 238 (17.5%) were diagnosed with DED. There was a significant association between the presence of DED and higher blood glucose (P < 0.001, OR1.240) as well as higher levels of glycosylated hemoglobin HbA1c (P < 0.001, OR1.108). Corneal sensitivity was negatively correlated with the prevalence of DED (P = 0.02, OR0.973).ConclusionsThe prevalence of DED in this community-based study was 17.5%, which was lower than that observed in hospital-based studies. Diabetic patients with poor metabolic control were more likely to present with DED. A dry eye examination should be added to the routine screening of diabetes.
Highlights
This study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED
We examined the prevalence and clinical characteristics of DED in community-based type 2 diabetic patients in Shanghai, China, and explored the risk factors associated with DED in this group
The Diabetes Group had a significantly higher Body Mass Index (BMI), blood glucose, triglyceride and total cholesterol than the Healthy Group.,there was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups
Summary
This study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED. Among studies of diabetic patients, hospital-based studies enrolled patients who were in a more serious condition, such as those with a long duration of diabetes and higher level of HbA1C. Until now, it was unknown whether DED was prevalent in community-based populations. We examined the prevalence and clinical characteristics of DED in community-based type 2 diabetic patients in Shanghai, China, and explored the risk factors associated with DED in this group
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