Abstract
Presynaptic receptors were discovered sixty years ago. Their main function is to modulate transmitter release. They can be separated into ionotropic and metabotropic receptors. Presynaptic ionotropic receptors open ion channels in the presynaptic terminals. Presynaptic metabotropic receptors modulate ion channels, and can also modulate transmitter release by acting on the release machinery. The molecules that activate presynaptic receptors on a given terminal can originate from the same presynaptic terminal, from neighbouring ones, but also from the postsynaptic target, from neighbouring glial cells and from distant sources.
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