Abstract
The mechanism involved in presynaptic modulation of transmitter release was studied in an identified synapse of Aplysia californica. Presynaptic hyperpolarization induces a decrease in the evoked postsynaptic potential amplitude 21. This is shown to be due to a reduction in the presynaptic spike amplitude during the hyperpolarization. The decreased presynaptic spike amplitude with hyperpolarization is explained as resulting from the superimposition of an early outward potassium current on the transient inward current. It is suggested that the presynaptic hyperpolarizing conditioning pulse decreases inactivation of the early outward current, which shunts the transient inward current. The superimposition of these two currents (transient inward current and the early outward current) induces a decrease in presynaptic spike amplitude, which in turn reduces the synaptic output from the terminal.
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