Abstract
In this study, the pressurized liquid extraction (PLE) of total phenolic content (TPC), gallic acid (GA), and p-hydroxybenzoic acid (PHBA) from Pseuderanthemum palatiferum (Nees) Radlk. leaves was optimized using response surface methodology. The extract at the optimum conditions of TPC, namely OP, was characterized using GC–MS, HPLC, and spectrophotometry analysis. Furthermore, bio-functional properties of the OP, including antioxidant, antimicrobial, antihypertensive activities, and cytotoxicity against cancer and normal cell lines, were also investigated. The results showed that all extraction models were appropriate in predicting the extraction processes (p < 0.05) of the target compounds. In addition to TPC, GA, and PHBA, the OP also contains a high amount of other valuable components that contributed to its highly biological activities. Moreover, the OP was nontoxic on HaCaT cells with a concentration of no more than 1000 µg/mL. From the obtained results, PLE proved to be a suitable technique for the recovery of bioactive compounds from P. palatiferum leaves.
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