Abstract
The work reports the results of an analysis of the lidocaine molecule conformational behavior in a supercritical carbon dioxide medium. Based on the nuclear Overhauser effect spectroscopy (2D NOESY) data, the authors determine the fractions of lidocaine molecule conformers in scCO2 at temperatures and pressures exceeding the critical point (308.15 K; 10–20 MPa). The paper also shows the effect of conformational inversion for this system at 308.15 K and 22 MPa. Since lidocaine polymorphic transformations can be accompanied by changes in the molecule conformation in the crystal elemental unit cell, it is quite urgent to determine the conformer fractions of this compound.
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