Pressure and Fluorescence Dual Signal Readout CuO-NiO/C Heterojunction Nanofibers-Based Nanoplatform for Imaging and Detection of Target Cancer Cells in Blood

Abstract

The development of multifunctional nanoplatform, which integrates biosensing and imaging diagnosis, for accurate identification of cancer cells in blood or other bodily fluids is critical for early cancer diagnosis and treatment. Herein, by using a facile single spinneret electrospinning technique followed by thermal treatment, CuO-NiO/C heterojunction nanofiber was synthesized. The resultant CuO-NiO/C nanofibers exhibited excellent catalytic activity toward ammonia borane (AB) hydrolysis, producing a marked pressure increase in a closed reaction vessel. Moreover, the resultant nanofibers showed highly efficient catalytic activity for reduction of rhodamine 6G (Rh6G, fluorescent molecule), accompanied by the fluorescence quenching. On the basis of these findings, a novel sensing platform utilizing folic-acid (FA) conjugated CuO-NiO/C nanofibers as an artificial enzyme and recognition element for fluorescence imaging and pressure-based (pressure meter) detection of folate receptor (FR)-positive cancer cell...