Abstract
We have characterised pressor responses to stimulation of the ureter in anaesthetised rats ( n = 20) as a model of acute visceral pain. The left ureter was cannulated close to the bladder and graded stimuli applied (5–90 mmHg, 30 s). The threshold was ∼25 mmHg. Suprathreshold pressures evoked responses proportional to the stimulus intensity, which were little altered when stimulation of the kidney was prevented by ligation of the ureteric-pelvic junction. The stimulus response curve was dose-dependently attenuated by morphine (1–3 mg kg −1 i.v.), in a naloxone reversible mariner. The characteristics of the responses observed correlate well with pain sensation in man and with the properties of ureteric primary afferent neurones in animals.
Published Version
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