Abstract
BackgroundBreast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this study was to explore the presence of HPV DNA in a case-control study.MethodsWe performed our study including 251 cases (breast cancer) and 186 controls (benign breast tumors), using three different molecular techniques with PCR (GP5/GP6, CLART® and DIRECT FLOW CHIP®).ResultsHPV DNA was evidenced in 51.8% of the cases and in 26.3% of the controls (p < 0.001). HPV-16 was the most prevalent serotype. The odds ratio (OR) of HPV within a multivariate model, taking into account age and breastfeeding, was 4.034.ConclusionsOur study, with methodological rigour and a sample size not previously found in the literature, demonstrate a significant presence of HPV DNA in breast cancer samples. A possible causal relationship, or mediation or not as a cofactor, remains to be established by future studies.
Highlights
Breast cancer is one of the most important neoplasia among women
The following inclusion criteria were established: women subjected to surgical treatment due to infiltrating breast cancer and/or carcinoma in situ or benign breast disease; patients over 18 years of age; surgical specimens embedded in paraffin, in adequate conditions and sufficient amount of tissue for the purposes of the study; and the obtainment of written informed consent
This is justified on the basis of the natural courses of breast cancer and benign disease, and the curves corresponding to breast cancer and benign disease by ages described by the World Health Organization (WHO) [4] are analogous to those of our own study
Summary
Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, Human Papilloma Virus (HPV). Breast cancer is the most commonly diagnosed malignancy in women [1,2,3]. It is estimated that 1.7 million new cases were diagnosed in 2012, representing 11.9% of all cancers diagnosed worldwide in both genders, and 25% of those diagnosed in women [3, 4]. Breast cancer is the most common malignancy in Spanish women, representing 29% of all female malignancies. Most of the cases are diagnosed in patients between 45 and 65 years of age [5]. Several risk factors have been cited in the literature, including patient age, gender, hormone therapy, the number of offspring, breastfeeding or different eating habits. A number of viruses have been identified to date in breast cancer tissues. The three main viruses are Epstein Barr virus (EBV), mouse
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
