Abstract
The administration of frog anterior pituitary homogenate to tadpoles promoted growth and increase of the amounts of connective tissue of the tail. Correlated with the morphological effect of the homogenate on the tadpole tails, collagen synthesis of the tail fin was markedly stimulated. Bovine growth hormone as well as bovine prolactin enhanced collagen synthesis of the tadpole tail fin, although the activity of the former seems to be less than that of the latter. Judging from the stimulated rate of 14C-proline incorporation into the collagen fraction, frog anterior pituitary homogenate appears to be more effective in promoting the growth of the tadpole than mammalian growth hormone or prolactin. The possibility that growth-promoting activity of the frog pituitary homogenate may be a combined action of prolactinlike and GH-like factors still remains.
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