Abstract
The asymmetric cell division during female meiosis requires the migration of meiotic spindle toward the peripheral position so that a tiny polar body can be extruded. Such asymmetrical division is essential for the egg to retain the maximum volume of the cytoplasm, necessary for supporting early embryo development. A recent study demonstrated the importance of metaphase cytoplasmic microtubule organizing centers (mcMTOCs) in regulating spindle positioning and faithful chromosome segregation to protect against aneuploidy in mouse oocytes.
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