Abstract
BackgroundVariation in prescription of antibiotics in primary care can indicate poor clinical practice that contributes to the increase of resistant strains. General Practitioners (GPs), as a professional group, are expected to have a fairly homogeneous prescribing style. In this paper, we describe variation in prescribing style within and across groups of GPs from six countries.MethodsCross-sectional study with the inclusion of 457 GPs and 6394 sore throat patients. We describe variation in prescribing antibiotics for sore throat patients across six countries and assess whether variation in “prescribing style” – understood as a subjective tendency to prescribe – has an important effect on variation in prescription of antibiotics by using the concept of prescribing style as a latent variable in a multivariable model. We report variation as a Median Odds Ratio (MOR) which is the transformation of the random effect variance onto an odds ratio; Thus, MOR = 1 means similar odds or strict homogeneity between GPs’ prescribing style, while a MOR higher than 1 denotes heterogeneity in prescribing style.ResultsIn all countries some GPs always prescribed antibiotics to all their patients, while other GPs never did. After adjusting for patient and GP characteristics, prescribing style in the group of GPs from Russia was about three times more heterogeneous than the prescribing style in the group of GPs from Denmark – Median Odds Ratio (6.8, 95% CI 3.1;8.8) and (2.6, 95% CI 2.2;4.4) respectively.ConclusionPrescribing style is an important source of variation in prescription of antibiotics within and across countries, even after adjusting for patient and GP characteristics. Interventions aimed at influencing the prescribing style of GPs must encompass context-specific actions at the policy-making level alongside GP-targeted interventions to enable GPs to react more objectively to the external demands that are in place when making the decision of prescribing antibiotics or not.
Highlights
Variation in prescription of antibiotics in primary care can indicate poor clinical practice that contributes to the increase of resistant strains
Variation in prescription of antibiotics within and across countries is a problem of increasing concern [1,2,3] that needs to be seriously addressed in primary care as more than 80% of the antibiotics are prescribed at this level [4,5]
We developed three models to estimate variance in prescribing style, and to investigate whether this variation is affected by patient characteristics and General Practitioners (GPs) characteristics
Summary
Variation in prescription of antibiotics in primary care can indicate poor clinical practice that contributes to the increase of resistant strains. Cordoba et al BMC Family Practice (2015) 16:7 of primary care services [14,15], and in consequence part of the solution is within the control of medical practice As part of this individual approach, previous qualitative and quantitative studies have shown that part of the variation can be explained by the subjective tendency that makes a GP to be more or less inclined to prescribe antibiotics [3,16,17,18]. Throughout the paper, we call this subjective tendency “prescribing style”
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