Abstract
FMF diagnosis is made clinically and may be supported by identifying mutations in the MEFV gene. The most commonly used diagnostic criteria for FMF are those of Tel Hashomer and the Livneh criteria, which have been established in the Jewish adult population. Recently, a Turkish group (Yalcinkaya-Ozen) proposed new criteria for diagnosis of FMF in children.
Highlights
FMF diagnosis is made clinically and may be supported by identifying mutations in the MEFV gene
When we used at least three pediatric criteria, the discrimination of the diseases other than FMF reached the highest specificity of 88.2% and the positive predictive value (PPV) of 82.9% at the expense of sensitivity
The Tel Hashomer diagnostic criteria were found to have high specificity (97.7%) for the diagnosis of FMF, whereas pediatric criteria had a higher sensitivity (87.4%) if at least two out of its five criteria were met
Summary
FMF diagnosis is made clinically and may be supported by identifying mutations in the MEFV gene. PReS-FINAL-2207: Results from a multicenter international registry of Familial Mediterranean Fever: validation of the new set of pediatric diagnostic criteria The most commonly used diagnostic criteria for FMF are those of Tel Hashomer and the Livneh criteria, which have been established in the Jewish adult population.
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