Abstract
Juvenile idiopathic arthritis (JIA) is a common chronic inflammatory diseases in childhood. Despite remission as a result of a plethora of treatment techniques, the chronic and relapsing nature of the disease requires continuous treatment which causes adverse side effects. It is important to uncover a biomarker that can efficiently predict patient responses to therapy as well as determine if patients will progress or regress as a result of treatment. Micro vesicles are key messengers containing many immune signaling molecules including cytokines, molecules known to play a major role in JIA.
Highlights
Juvenile idiopathic arthritis (JIA) is a common chronic inflammatory diseases in childhood
Due to the localized inflammation seen in JIA, we aim to analyze if micro vesicles isolated from patients can provide a source of biomarkers, giving specific information on molecules that can be targeted for treatment and allow the disease state to be monitored
Ultra-centrifugation isolated vesicles express lower levels of IL-6, MIF, TNF-R1, CXCL9 and S100 A12 when compared to whole plasma and healthy control vesicles
Summary
Juvenile idiopathic arthritis (JIA) is a common chronic inflammatory diseases in childhood. Despite remission as a result of a plethora of treatment techniques, the chronic and relapsing nature of the disease requires continuous treatment which causes adverse side effects. It is important to uncover a biomarker that can efficiently predict patient responses to therapy as well as determine if patients will progress or regress as a result of treatment. Micro vesicles are key messengers containing many immune signaling molecules including cytokines, molecules known to play a major role in JIA
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