Abstract
Background Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory diseases in childhood. In adult patients with rheumatoid arthritis there is large body of evidence supporting the presence of insulin resistance (IR) mainly linked to the underlying inflammation; severity and duration of the disease influence insulin sensitivity and increase the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus.
Highlights
Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory diseases in childhood
Both groups after oral glucose tolerance test (OGTT) did not show impaired glucose metabolism, statistically significant difference was found in fasting insulin which was higher in the JIA group (14,8±27.6 vs 4.8±2.0; p 0.011)
There was a significant difference between the two groups in terms of insulin resistance indexes: HOMA-IR (1.55±1.21 in JIA vs 1.05±0.49 in controls, p 0.011), QUICKI (4.25±3.07 in JIA vs 1.17±0.16 in controls, p 0.0001) and WBISI (5.24±6.03 in JIA vs 10.87 ±3.59 in controls, p 0.0001)
Summary
Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory diseases in childhood. In adult patients with rheumatoid arthritis there is large body of evidence supporting the presence of insulin resistance (IR) mainly linked to the underlying inflammation; severity and duration of the disease influence insulin sensitivity and increase the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Aim To evaluate the presence of IR in non-obese prepubertal children affected by JIA, compared with healthy controls matched for age, sex and BMI
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