Abstract
The time-saving, economical and practical advantages that are obtained when closed-loop recycling chromatography under overload conditions and peak shaving is applied for the preparative chromatographic separations of enantiomers on chiral stationary phases are described. The results of this study indicate that this kind of operation presents an alternative means for the preparation of pure enantiomeric compounds on a large-scale starting from racemic mixtures to the stereoselective synthetic and enzymatic routes currently available. The straightforward scaling up of the procedure from an analytical scale to gram amounts per day in the laboratory or even multi-kilogram separations by automated industrial production chromatography was demonstrated using mixtures of synthetically prepared racemates mainly of pharmaceutical interest.
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