Abstract
The development of pH sensitive, biocompatible and biodegradable hydrogels as novel drug delivery systems was carried out to achieve localized drug delivery. Poly[N-vinyl pyrrolidone-acrylic acid]-polyethylene glycol (Poly[NVP-AA]-PEG) interpolymer type systems were prepared by free radical polymerization. Azobisisobutyronitrile (AIBN) was used for initiating the polymerization and N,N″-methylene bisacrylamide was employed as a crosslinking agent. The concentration of initiator and crosslinking agent were varied and the reaction parameters were optimized. The obtained poly[NVP-AA]-PEG hydrogels were fully characterized by fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and optical microscopy (OPM). The equilibrium swelling studies were carried out in simulated gastric fluid (SGF) of pH 1.2 and simulated intestinal fluid (SIF) of pH 6.8. The gels were swollen extensively in SIF when compared to SGF. The influence of pH on the swelling of the hydrogel was also studied in buffers of varying pH. 5-Fluorouracil (5-FU) was loaded and the in vitro release studies were carried out in SGF. The results of this study suggest that poly [NVP-AA]-PEG hydrogels could be useful for localized delivery of drugs in the stomach.
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