Abstract
Micro-fiber films of poly(l-lactic acid)/silk fibroin as sheath and polyoxyethylene/ sodium l-ascorbic acid-2-phosphate as core were prepared successfully by coaxial electrospinning, and the structure and release behavior of films were also studied. Through the regulation of weight ratio of poly(l-lactic acid)- silk fibroin, the release behavior of micro-fiber films could be controlled. In our work, poly(l-lactic acid) and silk fibroin mixture solutions were spun as shell, and polyoxyethylene with amphiphilicity was spun as one component of core for the improvement of compatibility of sodium l-ascorbic acid-2- phosphate and poly(l-lactic acid). Due to the presence of silk fibroin, the structure of the sheath layers of micro-fiber films became irregular, and micro-fiber films with poly(l-lactic acid) and silk fibroin as sheath materials exhibited a higher release (79%) of l-ascorbic acid-2-phosphate in the first 10 h compared with that (18%) with pure poly(l-lactic acid) as sheath materials.
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