Preparation, standardization, and in vitro anti-inflammatory action of Navatchara aakiranam

Abstract

Background: Siddha system is a traditional system belonging to South India. An estimated 134 million Indians are thought to have chronic sinusitis, which can cause incapacitating headaches, fever, and nasal congestion and blockage, among other symptoms. Aakiranam is one among 32 types of external medicine that is therapeutically more effective due to its quicker mode of absorption. However, these traditional formulations are less validated scientifically. Objective: This study aims at the preparation, standardisation and evaluation of in vitro anti-inflammatory activity of Navatchara aakiranam (NA), a Siddha classical Herbomineral formulation. Materials and Methods: Physicochemical analysis, sophisticated instrumental analysis, such as Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive x-ray analysis, and inductively coupled plasma- optical emission spectroscopy studies, and in vitro anti-inflammatory using bovine serum albumin study were conducted on NA. Results: The study drug NA selected from the Siddha classical text “Gunapadam - Thathu Jeeva Vagupu” by Dr. Thiyagarajan R.L.I.M is taken for the first preliminary study as it is a potential as snuff in the treatment of sinusitis. Conclusion: This study validates the standardization of NA through organoleptic, biochemical, physicochemical, microbial load, and instrumental analyses.