Abstract
Cisplatin, a drug for the treatment of many kinds of cancer, was investigated to be supported on titanates. Both K2Ti4O9 and its hydrolyzed product H2Ti4O9•H2O selectively took up its aquoion, cis[Pt(NH3)2(H2O)2]2+, in its aqueous solution with pH=5-9 adjusted with HCl and NaOH. Its captured amounts were 4.93×10-2 mole for a mole of K2Ti4O9 and 4.73×10-2 mole for a mole of H2Ti4O9•H2O, respectively. About a quarter of them was released to the aqueous solution in pH=7.2-7.8 comparable to body fluid. For its magnetic targeting in drug delivery system, magnetite powder was coated with a sol obtained from a mixture of titanium n-butoxide, potassium acetate and acetic acid in ethanol. Its fired product at 600°C was a mixture of magnetic Fe3O4 with a cation exchangeable K2TiO3. It could uptake the cisplatin aquoion selectively from the diluted aqueous solution in 7.2 ppm concentration.
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