Abstract
The surface of SiO2 coated magnetic nanoparticles (NMPs) was modified by bonding with sulfobutylether-β-cyclodextrin (SBE-β-CD) via carbodiimide activation for the first time. The magnetic nanoparticles were synthesized by chemical coprecipitation method under alkaline condition, and the magnetic particles were modified by citric acid. Then the surface of obtained magnetic nanoparticles was coated with SiO2, and SBE-β-CD modified by citric acid was bonded to the surface of Fe3O4/SiO2 MNPs under carbodiimide activation method. The synthesized functionalized magnetic nanoparticles were characterized by X-ray Diffraction, Fourier Transform Infra-Red spectroscopy, thermogravimetric analyses and transmission electron microscopy. These functional nano-sized particles were scrutinized for enantioselective liquid-liquid extraction of five racemic drugs/intermediates, including trans-paroxol, N-methyl duloxetine, fluoxetine, tropic acid and acetyltropic acid, and it was found that compared with traditional SBE-β-CD, the present magnetic silica nanoparticles bonded with SBE-β-CD showed higher enantiorecognition with some racemates using enantioselective liquid-liquid extractions. To our knowledge, this is the first-time report on preparation and application of magnetic nanoparticles bonded with SBE-β-CD in enantioselective liquid-liquid extraction for chiral separations.
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