Abstract
The present study intended to stabilize the nanosuspension of powerful antioxidants such as genistein, quercetin, as well as caffeic acid from the leaves related to Asplenium scolopendrium by utilizing the RESSAS process. These compounds offer low efficacy and bioavailability since they are barely soluble in aqueous media. Thus, producing stable nanosuspensions can resolve this problem by reducing the size of the particle. In addition, central composite design (CCD) was used for analyzing the impact of oven temperature, pressure, CO2 flow rate, and modifier volume on the antioxidant activity index (AAI) in the outcome of RESSAS process. Further, DLS, FE-SEM, and LC-MS techniques were implemented for evaluating the nanosuspension features. Based on the results, the behavior of the particles after forming particle was emphasized, which indicated that the RESSAS process results in diminished agglomeration of the particle and enhanced AAI for the extract. Thus, the bioavailability of the products related to herbal medicinal can be dramatically increased in biological media.
Published Version
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