Preparation of redispersible dry emulsion using Eudragit E100 as both solid carrier and unique emulsifier

Abstract

To improve the patient's compliance and the physical stability of liquid emulsion, a novel dry emulsion being able to reform the original O/W-emulsion by reconstitution in artificial gastric fluid is presented. Dry emulsions were prepared by spreading liquid O/W-emulsions on a flat glass, dried at the oven maintained at 40 °C and then triturated to powders with suitable particle size. When the dry emulsions were immersed into gastric fluid, stable emulsions were formed in 5 min. Here a sole excipient, high polymer, was applied as both solid carrier and unique emulsifier, and Zedoary turmeric oil (ZTO) was used as a model drug. In this study the effects of different kinds of high polymers on the liquid emulsion and on the dispersibility of the dry emulsions were investigated. Eudragit E100 exhibited the best emulsifying ability and the dry emulsion prepared with it shows the quickest release property. And the mean emulsion droplet sizes of the original emulsions and the reconstruction emulsions were <1 μm. Here the basic properties of the polymers, such as contact angle and relative viscosity, were also investigated. With this method it was easy to prepare redispersible dry emulsion from liquid oil content up to 45%.