Abstract
Poly-D,L-Lactide/ε-caprolactone (PDLLA-ε-CL) and β-tri-calcium phosphate (β-TCP) composites were prepared for the development of a degradable material as an alternative for injectable filling material in bone tissue repair. For this purpose, β-TCP was synthesized by wet precipitation method. β-TCP was characterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometer (XRD), Zeta-SIZER and Brunauer–Emmett–Teller (BET) analyser. PDLLA-ε-CL co-polymer was synthesized under nitrogen (N2) atmosphere using ring-opening polymerization using stannous octoate as catalyst. Chemical structures of copolymers were determined by FTIR and Proton Nuclear Magnetic Resonance (H-NMR) analysis. Average molecular weight of copolymers were identified with Gel Permeation Chromatography (GPC). (PDLLA-ε-CL)-β-TCP composites were prepared by loading differing amounts of β-TCP to the co-polymer. The resulting composites were easily shaped by hand. The degradation profiles of the composites were determined by monitoring the changes in the molecular weight of the co-polymers over a period of 49 days. Degradation rate of the composites decreased as the percentage of β-TCP in the structure increased
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