Preparation of New Polymeric Active Coatings for Vascular Applications, Based on Biocompatible Acrylic Systems with Anti-Inflammatory Components

Abstract

Data on the preparation of hydrophilic polymeric systems based on copolymers of 2- hydroxyethyl methacrylate H, with new acrylic derivatives of 4-methoxyphenylacetic acid or Ibuprofen (drugs widely used as analgesic and non-steroidic anti-inflammatory agents) are presented. The copolymer systems prepared with 5–20% of the pharmacologically active acrylic derivative form hydrophilic films when a solution of the prescribed concentration is applied as a coating of biomaterials used for the preparation of vascular implants like knitted or woven meshes of Dacron or small-diameter vascular grafts of Goretex. After evaporation, thin films with good adhesion to the porous surface are obtrined, and the polymeric coating remains in standard flow conditions. The absorption of water after immersion of films in a buffered solution at pH = 7.2 was followed gravimetrically and the swelling behaviour at the equilibrium was analysed considering the average composition of the acrylic copolymer systems used in the present work.