Abstract
Subcritical water (SCW) as a solvent and aqueous solution of polyethylene glycol (PEG) as an antisolvent were used to prepare curcumin (CUR) nano-particles. The effects of SCW temperature (110–150 ℃), antisolvent temperature (0 and 20 ℃) and PEG concentration (0.05–0.50 wt%) were studied by univariable method. At the selected conditions of 140 °C, 0 °C, and 0.50 wt%, based on the SEM image analysis, the average lateral size and thickness of the nano-flower CUR particles were nearly 485 nm and 83 nm, respectively. Dynamic light scattering (DLS) showed a highly monodispersed nanoparticles with the mean particle size of 119 nm. FTIR and XRD analyses confirmed no structural degradation, and significant decrease in crystallinity index, respectively. Furthermore, the dissolution rate and antioxidant activity of the nano-flower CUR were significantly higher than the raw CUR, remained unchanged after 60 days, confirming the stability and functionality of the produced nanoparticles.
Published Version
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