Abstract
Epitope molecularly imprinted polymers (EMIPs) were synthesized using a novel cyclodextrin-based ionic liquid as functional monomer for specific recognition of cytochrome c (Cyt c) in aqueous solution via the combination of epitope and surface imprinting approach. Herein, the surface-exposed C-terminus of Cyt c (residues 96–104, AYLKKATNE) was selected as the template. Results reveal that the charged monomer cyclodextrins (CDs), namely mono-6A-deoxy-6-(1-vinylimidazolium)-β-cyclodextrin tosylate, could confer EMIPs with superior adsorption (67.6mgg−1) and excellent recognition property (4.54) toward Cyt c due to its multiple binding sites with template such as hydrogen bonding, π–π effect, electrostatic, hydrophobic as well as steric effects. Moreover, the magnetic property of EMIPs has endowed the whole separation process with great convenience and efficiency, which demonstrated their potential application for large-scale separation and recognition.
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