Preparation of Magnetic Cu(II) Nano-structure (Based on Nano-Fe3O4) and Application to the Synthesis of Hexahydroquinoline Derivatives

Abstract

A nanomagnetic catalyst based on the nano-Fe3O4 core was synthesized and used in the synthesis of the hexahydroquinoline derivatives which acts as a solid heterogeneous catalyst. The as-prepared catalyst was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, vibrational sample magnetometry, and thermal gravimetric analysis. Catalyst activity was tested in the synthesis of hexahydroquinoline derivatives. The FTIR shows that the catalyst can activate as the carbonyl group of the benzaldehyde, so that it can motivate the reaction. The proposed method has important features which include solvent free, mild, high yield, shorter reaction time, easy preparation and separation of the catalyst, and efficient workup procedure. On the other hand, the design of experiment was used as a systematic method for the programing of the reaction condition. Optimization showed that the optimal reaction temperature and amount of catalyst were 65 °C and 0.05 g, respectively.