Abstract
The Fe3O4/reduced graphene oxide (Fe3O4/RGO) nanocomposites with good dispersibility were synthesized for targeted delivery of paclitaxel (PTX). Firstly, the superparamagnetic Fe3O4/functional GO nanocomposites were prepared via hydrothermal method in which GO sheets were modified by surfactant wrapping. The Fe3O4/RGO nanocomposites were successively prepared through the reduction of graphene oxide. The products were investigated by Fourier-transform infrared spectrum, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and vibration sample magnetometry. It was found that spherical Fe3O4 nanoparticles were uniformly anchored over the RGO matrix and the nanocomposites were superparamagnetic with saturation magnetization (Ms) of 9.39 emu/g. Then PTX was loaded onto Fe3O4/RGO nanocomposites, and the drug loading capacity was 67.9%. Cell viability experiments performed on MCF-7 demonstrated that the Fe3O4/RGO-loaded PTX (Fe3O4/RGO/PTX) showed cytotoxicity to MCF-7, whereas the Fe3O4/RGO displayed no obvious cytotoxicity. The above results indicated that Fe3O4/RGO/PTX nanocomposites had potential application in tumor-targeted chemotherapy.
Highlights
Paclitaxel (PTX) is used for the first-line chemotherapeutics in breast cancer, lung cancer, and so on [1]
Recent research showed that magnetic nanoparticles (MNPs) could be attached to graphene, which can be applied in magnetic resonance imaging [15], targeted drug delivery [16, 17], biocompatible adsorbent [18], magnetic solid phase extraction [19], microwave electromagnetic [20], Schottky diode applications [21], and biomolecule immobilization [22]
The magnetic graphene oxide (Fe3O4/GO) for delivering PTX was prepared by hydrothermal method, and Fe3O4/GO was subsequently reduced to Fe3O4/RGO with good dispersibility
Summary
Paclitaxel (PTX) is used for the first-line chemotherapeutics in breast cancer, lung cancer, and so on [1]. The graphene nanocomposites were studied for drug loading and delivery, since the hydrophobic drugs can be loaded on to graphene sheets by π-π stacking. Angelopoulou et al developed GO/PLA-PEG nanocomposites loading with PTX, which showed satisfactory high loading capacity, controlled release, and cytoxicity against A549 cancer cells [10]. Zhang et al synthesized PEG modified nano graphene oxide for delivering PTX and indocyanine green (ICG), which had good fluorescence labeling and therapy effect [11]. The bifunctional graphene drug delivery system for magnetic targeting and drug loading was developed in this paper. The magnetic graphene oxide (Fe3O4/GO) for delivering PTX was prepared by hydrothermal method, and Fe3O4/GO was subsequently reduced to Fe3O4/RGO with good dispersibility. The Fe3O4/RGO nanocomposites were characterized, and the drug loading and release of PTX were investigated. The inhibitory effect of Fe3O4/RGO-loaded PTX (Fe3O4/RGO/PTX) on MCF-7 cells was conducted
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