Abstract
AbstractWe have proposed and synthesized several new structural classes of Cerulenin analogues, which have potential as inhibitors of both fatty acid and polyketide synthase multi‐enzyme complexes. These analogues contain cis epoxides bearing flanking carboxylate groups. Our syntheses have been designed to allow access to a wide range of fatty acid and polyketide‐like side chains from readily available starting materials in convergent fashion in just four to five steps. In total, ˜40 potential analogues have been prepared and characterized, covering all the structural sub‐classes proposed, the majority of which constitute novel functional groupings.
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