Abstract
ZrO2 is bioceramic known for its excellent chemical stability and biocompatibility. Porous ZrO2, with its large surface area, has attracted considerable attention in the field of orthopedic implant drug delivery. However, the shortcomings of poor bioactivity and insufficient drug loading capacity in traditionally prepared porous ZrO2 limit its application. In this paper, graded ordered porous ZrO2 with interconnected open pores was prepared by colloid crystal templating, which exhibited large specific surface area and excellent slow-release properties. Then, it was surface-coated with chitosan (CS) possessing bioactivity and strong adsorption capacity. Factors affecting microscopic morphology, drug loading and slow-release properties of this composite were systematically investigated using ibuprofen (IBU) as a drug model. Results showed that graded ordered porous ZrO2 significantly enhanced drug loading capacity compared to normal ordered porous ZrO2, reaching 125.66 mg/g. Additionally, surface coating modification of the composite by CS significantly affected IBU loading capacity. By regulating process parameters such as CS concentration and coating time, high-efficiency loading of IBU was realized and drug loading capacity reached up to 194.17 mg/g. In vitro drug simulation experiments showed that CS coating effectively controlled the initial burst release of IBU and prolonged the effective release time; maximum cumulative release rate reached 93.7 %. This study provides a new idea for implantable drug sustained-release systems, which may better meet medical needs.
Published Version
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