Abstract
In this study, copper oxide nanoparticles (CuO NPs) were successfully prepared by a sımple chemical method. After conjugation of methotrexate (MTX) on bovine serum albumin (BSA), the surfaces of CuO NPs were functionalized with BSA-MTX for the formation of CuO@BSA-MTX NPs. The samples were characterized by ultraviolet visible (UV–vis), Fourier-transform infrared (FT-IR), transmission electron microscopy (TEM) and atomic force microscopy (AFM) analyses. It was fund that the synthesized CuO@BSA-MTX NPs show spherical shape, and exhibited a uniform morphology. Also the release study shows that the release of MTX is faster and more in the presence of proteinase K. The cytotoxicity of CuO@BSA-MTX NPs against MDA-MB-231 breast cancer cells was investigated with MTT assay. The results revealed that CuO@BSA-MTX NPs show significant cytotoxicity on MDA-MB-231 cell line.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
