Abstract
Background: Orally disintegrating tablets (ODTs) have gained an increasing interest in the pharmaceutical industry for the last years. Several technologies have been sophisticated for ODTs to improve patient compliance. In the present work, an attempt has been made to formulate and evaluate cinnarizine, a drug for motion sickness, in an easy to administer, rapid disintegrated dosage form (oral lyophilizates with enhanced disintegration and dissolution profile and consequent potential improvement in bioavailability.Materials and Methods: Cinnarizine oral lyophilizates were prepared by dispersing the drug in an aqueous solution of mannitol, hydroxypropyl methyl cellulose, and glycine. Different formulations were prepared by freeze-drying (lyophilisation) technique. The effect of concentration of mannitol, hydroxypropyl methyl cellulose, and freezing time on the lyophilizates characteristics was investigated. The drug-excipient interaction was investigated as well.Results: The resulting cinnarizine oral lyophilizates showed an enhanced disintegration (27.5±3.53 sec to 56±12.73 sec) and enhanced dissolution profile (25.09% to 44.7% after two minutes). The infrared spectroscopic studies showed no drug-excipient interactions. Furthermore, increasing the concentration of mannitol, increasing the concentration of hydroxypropyl methyl cellulose and duplication of the duration of freezing time had a negative influence on the disintegration and dissolution properties of the resulting lyophilizates.Conclusion: Cinnarizine oral lyophilizates were successfully prepared and resulted in a rapid disintegration, high dissolution profile, with stable characteristics and without noticeable drug-excipient interaction.
Highlights
According to the World Health Organization's reports on Global Health and Aging, there would be an increase in the population aged 65 or older from an estimated 0.5 billion in 2010 to nearly 1.5 billion in 2050.1 Difficulty in swallowing is an important problem in orally administered drugs in solid dosage form for children and elderly patient.[2]
The aim of this study is to develop new orally disintegrating tablets (ODTs) of cinnarizine using the lyophilization method
In order to determine the effect of Hydroxy propyl methyl cellulose (HPMC) on the characteristics of cinnarizine oral lyophilizates, different formulas were prepared
Summary
According to the World Health Organization's reports on Global Health and Aging, there would be an increase in the population aged 65 or older from an estimated 0.5 billion in 2010 to nearly 1.5 billion in 2050.1 Difficulty in swallowing is an important problem in orally administered drugs in solid dosage form for children and elderly patient.[2] On the other hand, using of the liquid dosage form as an alternative has several limitations related to stability, storage, transportation and packaging.[3] For this reason, pharmaceutical industry has formulated orally disintegrating tablets (ODTs) which combine the advantages of both solid and liquid formulations. An attempt has been made to formulate and evaluate cinnarizine, a drug for motion sickness, in an easy to administer, rapid disintegrated dosage form
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