Abstract
Bacterial cellulose (BC) and silk fibroin (SF) double-network hydrogel with high mechanical strength and biocompatibility was synthesized by using BC as the novel polymer substrate to absorb aqueous SF solution as the modifier. Fundamental physical characterizations were carried out by scanning electron microscopy, energy dispersive spectrometry, fourier transform infrared spectrometry, X-ray diffraction and X-ray photoelectron spectroscopy. Thermogravimetric and differential thermal analysis was used to investigate the stability of the hydrogel. Strength and biocompatibility of the BC/SF hydrogel for cartilage tissue engineering were evaluated by tensile strength tester and cell culture experiments. Results reveal that the BC/SF double-network hydrogel was prepared successfully, and the hydrogel could be used as a cartilage repair material in clinical application.
Published Version
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