Preparation of amphiphilic cellulose carrier and study of its drug release performance

Abstract

With cellulose as raw material, esterification is carried out using the hydroxyl groups on the cellulose skeleton, and amphiphilic cellulose drug carrier is prepared. The structure and degree of crystallinity of the prepared drug carrier are analysed using Fourier transform infrared spectroscopy and X-ray diffraction. The drug release behaviour of the polymeric micelles was studied using aspirin as the model drug. The analysis shows that micelles were formed from the amphiphilic cellulosic polymers. The influence of the degree of cellulose modification on drug release efficiency is also discussed.