Abstract

In this paper, the oil-in-gelatin based tissue-mimicking materials (TMMs) doped with carbon based materials including carbon nanotube, graphene ink or lignin were prepared. The volume percent for gelatin based mixtures and oil based mixtures were both around 50%, and the doping amounts were 2 wt %, 4 wt %, and 6 wt %. The effect of doping material and amount on the microwave dielectric properties including dielectric constant and conductivity were investigated over an ultra-wide frequency range from 2 GHz to 20 GHz. The coaxial open-ended reflection technology was used to evaluate the microwave dielectric properties. Six measured values in different locations of each sample were averaged and the standard deviations of all the measured dielectric properties, including dielectric constant and conductivity, were less than one, indicating a good uniformity of the prepared samples. Without doping, the dielectric constant was equal to 23 ± 2 approximately. Results showed with doping of carbon based materials that the dielectric constant and conductivity both increased about 5% to 20%, and the increment was dependent on the doping amount. By proper selection of doping amount of the carbon based materials, the prepared material could map the required dielectric properties of special tissues. The proposed materials were suitable for the phantom used in the microwave medical imaging system.

Highlights

  • Microwave imaging (MWI) technology attracts much attention in medical use and seems an alternative imaging modality for the well developed modalities such as X-ray, ultrasound, or magnetic resonance imaging (MRI) due to some advantages including light and portability, low-cost, non-ionizing radiation, and imaging without the need of contrast agents [1,2,3,4,5]

  • The gelatin-based materials mixed with oil were typically used especially to imitate the dielectric properties of the human soft tissues, since they could provide a high competitiveness for the controllable and tunable characteristics of dielectric properties by varying the concentration of oil [9,10]

  • We focused on the doping effect of the carbon-based synthetic materials on the microwave dielectric properties of the oil-in-gelatin based tissue-mimicking materials (TMMs)

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Summary

Introduction

Microwave imaging (MWI) technology attracts much attention in medical use and seems an alternative imaging modality for the well developed modalities such as X-ray, ultrasound, or magnetic resonance imaging (MRI) due to some advantages including light and portability, low-cost, non-ionizing radiation, and imaging without the need of contrast agents [1,2,3,4,5]. PAG is typically comprised of Acrylamide (C3 H5 NO) polymerized in liquid solvent and used to simulate the behavior of biological tissues in applicators for microwave hyperthermia or in scaled-phantom experiments, with the advantages including excellent optical transparency and high elasticity [6,7]. The gelatin-based materials mixed with oil were typically used especially to imitate the dielectric properties of the human soft tissues, since they could provide a high competitiveness for the controllable and tunable characteristics of dielectric properties by varying the concentration of oil [9,10]. The microwave dielectric properties of the oil-in-gelatin based TMMs could not be tuned significantly by varying a small quantity of oil. The dielectric properties of the prepared TMMs usually provided a small tuning range through varying the volume percent of oil in general

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