Preparation of 99Mo/99mTc generator based on cross-linked chitosan polymer using low-specific activity (n,γ)99Mo

Abstract

The cross-linked chitosan polymer (CCM) is an emerging adsorbent matrix. The CCM matrix has very high adsorption for Mo and thus can be utilized to prepare 99Mo/99mTc generator using low-specific activity (n, γ) 99Mo. The elution efficiency of 99mTc from 99Mo/99mTc generator based on the CCM polymer oxidized and non-oxidized form has been found more than 75% and about 40%, respectively. The Na[99mTc]TcO4 eluates obtained were clear solutions with pH 5–6 and the R C Purities of 99%. The 99Mo breakthrough in the 99mTc fraction with alumina guard column (0.5 g) was 0.002 ± 0.003 (n = 9). The radionuclidic purity of 99mTcO4 − was more than 99.99%. The Al and Mo content in the eluted 99mTc was less than 10 µg/ml. The R C Purity of the labeled compounds was greater than 95%.