Abstract
Performance study of a computer controlled automated closed cyclic module for the separation and recovery of 99mTc from low specific activity (n, γ) 99Mo using methyl ethyl ketone (MEK) solvent extraction technique named 99Mo/99mTc-TCM-AUTOSOLEX (Technetium automated solvent extraction) Generator is described. The entire system is automated and controlled by a user-friendly PC based graphical user interface that actually supervises process via an embedded system based electronic controller. The average yield of separation of 99mTc was above 85 % and 99Mo breakthrough in 99mTc pertechnetate was 99 %, MEK content <0.1 % (v/v), Al and Mo content <10 µg/ml. R. C. Purity of 99mTc-radiopharmaceuticals studied was not less than 96 %. Bio-Quality control studies confirm that sodium pertechnetate obtained was sterile and pyrogen free. Imaging studies in animals and humans with limited radiopharmaceuticals show that the quality of 99mTc-pertechenate obtained in the present module was good enough to do clinical study.
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