Abstract
Some new hydrazinium salt of aromatic carboxylic acids have been prepared by neutralization of acid with hydrazine hydrate in aqueous medium and characterized by Analytical, IR spectral and TG-DTA analysis. All compounds undergo two, three or four step decomposition yielding carbon residue as the final product. The in vitro antibacterial screening of 2,4-dichlorophenoxyacetic acid and its hydrazinium salt against Escherichia coli have been investigated. The antibacterial activity of the prepared hydrazinium salt shows more promising activity than the free acid.
Highlights
Hydrazine is the simplest diamine and forms salt with mineral and carboxylic acids (Vogel, 1962; Yasodhai and Govindarajan, 1999)
Some new hydrazinium salt of aromatic carboxylic acids have been prepared by neutralization of acid with hydrazine hydrate in aqueous medium and characterized by Analytical, IR spectral and TG-DTA analysis
The preparation of hydrazinium salts has become a subject of recent interest due to their wide use as additives in propellants, drugs to treat cancer and Hodgkin’s diseases and explosives (Vogel, 1962)
Summary
Hydrazine is the simplest diamine and forms salt with mineral and carboxylic acids (Vogel, 1962; Yasodhai and Govindarajan, 1999). The preparation of hydrazinium salts has become a subject of recent interest due to their wide use as additives in propellants, drugs to treat cancer and Hodgkin’s diseases and explosives (Vogel, 1962) They have been used as ligands for the preparation of metal hydrazinium/hydrazine complexes (Patil et al, 1980, Govindarajan et al, 1986 a and b; Chandra and Singh, 1983). 2,4dichlorophenoxyacetic acid contain two potent chloro substituents It influences it to have antibacterial property like chloroxylenol (4-chloro2,5-Xylenol) which acts as antiseptic as well as disinfectants. This prompted us to make antibacterial study of hydrazinium salt of 2,4dichlorophenoxyacetic acid against Escherichia coli
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