Abstract
Preparation and study of homogeneous nanoparticles (NPs) have been an important area of research in recent years. In this work, we describe a polymer-protected method for the preparation and formation of realgar nanocomposites with various average diameters. Two types of macromolecules were selected and their interactions with nanorealgar were studied by spectrometric methods. It is found that the starch has a significant effect on the formation and growth of homogeneous nanorealgar with an average diameter of 30 nm. In the case of using polyvinylpyrrolidone (PVP) as a protecting polymer, the realgar NP size is in the range of 20–80 nm, with an average value of 55 nm. The polymer-protected nanorealgar shows superior antimicrobial activity against Escherichia coli and Staphylococcus aureus, whereas the bulky realgar colloid formed in aqueous solution has much less antimicrobial activity. The antimicrobial activity followed the order As4S4–starch NPs > As4S4–PVP NPs > As4S4 NPs, which suggests small realgar NPs are more favourable.
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