Preparation and Study of Stability Pharmaceutical Composition PSMA 11 and Radiopharmaceutical 99mtc PSMA 11 Labeled With 99mtc Radionuclide

Abstract

This work is devoted to the study of the synthesis of a pharmaceutical composition (PhC) [PSMA-11] in the form of a lyophilisate with optimization of the amount of ingredients and sodium pertechnetate (Na99mTcO4) from the 99mTc Generator to obtain the radiopharmaceutical [ 99mTc]-PSMA-11 with the highest possible radiochemical yield (RCY) and radiochemical purity (RCP). The stability of radiopharmaceutical [99mТс]- PSMA-11 in 0.9% NaCl solution and in human serum was determined. The preliminary shelf life of PhC [PSMA-11] was determined and set to 6 months.