Preparation and Size Control of Efficient and Safe Nanopesticides by Anodic Aluminum Oxide Templates-Assisted Method.

Chunxin Wang,Bo Cui,Yan Wang,Zhanghua Zeng,Liang Guo,Haixin Cui,Fei Gao,Changjiao Sun,Xiang Zhao,Mengjie Wang

doi:10.3390/ijms22158348

Abstract

Efficient and safe nanopesticides play an important role in pest control due to enhancing target efficiency and reducing undesirable side effects, which has become a hot spot in pesticide formulation research. However, the preparation methods of nanopesticides are facing critical challenges including low productivity, uneven particle size and batch differences. Here, we successfully developed a novel, versatile and tunable strategy for preparing buprofezin nanoparticles with tunable size via anodic aluminum oxide (AAO) template-assisted method, which exhibited better reproducibility and homogeneity comparing with the traditional method. The storage stability of nanoparticles at different temperatures was evaluated, and the release properties were also determined to evaluate the performance of nanoparticles. Moreover, the present method is further demonstrated to be easily applicable for insoluble drugs and be extended for the study of the physicochemical properties of drug particles with different sizes.

Highlights

Pesticides are widely used in protecting crops and improving crop yield to meet agricultural production [1,2]
The mean particle size of buprofezin nanoparticles (BNPs) based on a scanning electron microscope (SEM) image (Figure 1b) and a transmission electron microscope (TEM) image (Figure 1c) were 100 nm and 103 nm, respectively, which was smaller than the hydrated particle size (Figure 1a)
The size of each aperture of the template is consistent, and the template is arranged in order, so the prepared drug particles are uniform in size

Summary

Introduction

Pesticides are widely used in protecting crops and improving crop yield to meet agricultural production [1,2]. The research of the nanopesticide falls into two categories: one is to use nanotechnology including emulsification and homogenization to prepare nanoparticles and the other is to use nanomaterials to construct nanoparticles [9,10,11] The former is mainly affected by external factors including equipment and process parameters, it faces critical challenges including relatively large particle size difference, batch differences and low production efficiency [12,13,14,15]. Antagonistic effect of azoxystrobin poly (lactic acid) microspheres with controllable particle size was studied These studies showed a large influence of the preparation conditions on the drug particles [16,17]. The nanoparticles prepared by nanomaterials can ensure the uniformity of particle size [23,24]

Methods

Results

Conclusion