Abstract
High charge swelling micas are layered silicates used in adsorption of several inorganic and organic species. In this study, we evaluated the adsorption of chlorhexidine digluconate on highly charge mica Na-mica-4. Drug release and antibacterial action against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) using the direct contact test for mica/chlorhexidine hybrids were evaluated. The hybrids were characterized using X-ray diffraction, Fourier transform infrared spectroscopy, zeta potential measurements, CHN elemental analysis, and scanning electron microscopy. Chlorhexidine interacts successfully with the mica surface. The maximum amount of chlorhexidine incorporated was 583 mg g−1, and the characterizations indicated that electrostatic attraction between the protonated amino group of the drug and the negative surface of clay was predominant in the formation of hybrids. Release kinetics study indicated that 80% of the drug release occurred in the first 12 h. The antibacterial test proved to be dependent on the time of chlorhexidine release, reaching 100% inhibition against S. aureus and E. coli after 0.5 h and 6 h, respectively.
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