Abstract
This paper aims to construct a β-Cyclodextrin (β-CD)chlorohexidine (CHX) inclusion complex(β-CD-CHX) and to characterize its morphology, CHX release, cytotoxicity, and antimicrobial activity. β-CD-CHX was prepared by the saturated aqueous solution method. The results of SEM showed that β-CD-CHX was a fine needle-shaped crystalline particle; and the results based on the in-vitro release showed that β-CD-CHXhas excellent sustained-release property. The cytotoxicity and antimicrobial activity of β-CD-CHX against different concentrations (5 mg/L, 10 mg/L, 20 mg/L, 40 mg/L) were observed in cytotoxicity tests and bacteriostatic ring test, respectively. The cytotoxicity assay suggested that the solvent fractions were not cytotoxic to MC3T3-E1 at concentrations up to 20 mg/L. However, the concentration of 40 mg/L had marked cytotoxicity; the β-CD-CHX at different concentrations showed excellent antibacterial effect against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).
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