Abstract
Non-ionic surfactant vesicles (NSVs) were prepared from polysorbate 20 and cholesterol by means of two different methods: by direct sonication of an aqueous dispersion of the various components (bulk) or by solubilization of the components, evaporation of the organic solvent to form a film inside the vessel used for the preparation and then by sonication (film). The influence of the preparation technique on the properties of the obtained structures was studied. Vesicles with bigger dimensions and higher entrapment efficiency were obtained when sonication was carried out after the film formation. Vesicle formation in the presence of ionic surfactants was investigated in order to evaluate the effect of charged components on vesicle dimensions, entrapment efficiency and stability. Dimethyldioctadecylammonium bromide (DDOA) and cetylpyridinium chloride (CPy) were used to introduce a positive charge in the vesicle structure, while dicetylphosphate (DCP) was used for a negative charge. Better resistance to osmotic stress and higher entrapment efficiency values were obtained with vesicles containing DCP and CPy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
