Preparation and Physical Properties of PCL-Metoprolol Tartrate Electrospun Nanofibers as Drug Delivery System

Abstract

Electrospinning is considered a promising technology for encapsulating and loading various drugs into nanofibers. Metoprolol tartrate (MPT), hydrophilic therapy, was used as model drug. Metoprolol tartrate was loaded into poly(ɛ-caprolactone) (PCL) via blend and emulsion electospinning. The preparation processes, morphology, chemical structure thermal properties were evaluated. FESEM showed that emulsion electospinning produce larger fiber diameters(301.775nm) when compared to fibers produced by blend electrospinning(112.463, 249.34)nm, the PCL/ span 80 and MPT-PCL by emulsion method which have high fiber diameter than pure PCL and MPT-PCL by blend method and the Tm of pure PCL nanofibers and all drug loaded scaffolds are around 60°C from DSC test, water contact angle to pure PCL electrospun mats hydrophobic character (126.2°), while PCL/span 80, and PCL-drug nanofiber mats showed hydrophilic character. Our study demonstrated the possibility of using electrospinning with a promising good potential toward sustained and controlled drug delivery system.