Abstract
Water-soluble photosensitizing pharmaceutical of hypocrellin A (HA), prepared by embedding HA into porous hollow silica nanospheres, exhibited high singlet oxygen generation yield, good light stability and good thermal stability. Further, the in-vitro experiments indicated that such silica nanospheres containing HA can be efficiently taken up by HeLa cells, and light irradiation of such impregnated cells might result in significant cell death. Especially, HA cannot be released from silica nanospheres, which is beneficial to minimizing phototoxic side effects. Thus, these properties of HA-silica nanospheres could possibly make it especially promising to be used in clinical photodynamic therapy.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
